Buy PB-22 Online

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Buy PB-22 Online, (QUPIC or 1-pentyl-1H-indole-3-acid 8-quinolinyl ester) is a designer drug offered by online vendors as a cannabimimetic agent, and detected being sold in synthetic cannabis products in Japan in 2013. The structure of PB-22 appears to use an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear. PB-22 represents a structurally unique synthetic cannabinoid chemotype, since it contains an ester linker at the indole 3-position, rather than the precedented ketone of JWH-018 and its analogs, or the amide of APICA and its analogs.

PB-22 has an EC50 of 5.1 nM for human CB1 receptors, and 37 nM for human CB2 receptors. PB-22 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, suggesting potent cannabinoid-like activity. The magnitude and duration of hypothermia induced in rats by PB-22 was notably greater than JWH-018, AM-2201, UR-144, XLR-11, APICA, or STS-135, with a reduction of body temperature still observable six hours after dosing.

Description

Buy PB-22 Online

Buy PB-22 Online, PB-22 has an EC50 of 5.1 nM for human CB1 receptors, and 37 nM for human CB2 receptors. PB-22 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, suggesting potent cannabinoid-like activity. The magnitude and duration of hypothermia induced in rats by PB-22 was notably greater than JWH-018, AM-2201, UR-144, XLR-11, APICA, or STS-135, with a reduction of body temperature still observable six hours after dosing.

PB-22 (Item No. ISO00122) is an analytical reference material categorized as a synthetic cannabinoid. It mimics the effects of Δ9-THC (Item Nos. 12068 | ISO60157).1 PB-22 is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications. PB-22 Formal Name : 1- pentyl- 8- quinolinyl ester- 1H- indole- 3- carboxylic acid CAS Number : 1400742-17-7 Molecular Formula : C23H22N2O2 Formula Weight : 358.4 Formulation : A crystalline solid Purity : ≥98%.

Buy PB-22 Online, The construction of PB-22 seems to take advantage of an understanding of structure-activity interactions inside of the indole class of cannabimimetics, even though its structure roots tend to be uncertain. PB-22 represents a structurally distinctive chemotype, considering that it incorporates an ester linker right at the indole 3-position, as opposed to the precedented ketone of as well as its analogs, or even the amide of SDB-001 together with its analogs.

Buy PB-22 Online, PB-22 (1-pentyl-8-quinolinyl ester-1H-indole-3-carboxylic acid) and 5F-PB-22 (1-(5-fluoropentyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid) are new synthetic cannabinoids with a quinoline substructure and the first marketed substances with an ester bond linkage. WARNING This product is not for human or veterinary use.